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For more information: https://www.nfp79.ch/en https://actu.epfl.ch/news/two-epfl-scientists-win-grants-to-help-advancing-t/

In this review, Can summarizes findings on specialized cell types that arise during appendage regeneration, with a particular focus on regenerative skin cell populations. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.771040/full

Here, Can discusses how distinct cell types contribute to rebuilding different appendages, such as tails and limbs. This review challenges one-size-fits-all models of regeneration and highlights the importance of cellular context. https://royalsocietypublishing.org/rsob/article/11/7/210126/91068/Appendage-regeneration-is-context-dependent-at-the

We constructed a comparative single-cell transcriptomic map of regenerating and non-regenerating frog tadpole limbs, showing that regeneration reuses some of the limb-development–related cell populations. We further demonstrated that secreted inhibitory signals, arising from cartilage and bone, progressively restrict regenerative competence, reframing regeneration loss as an actively regulated process driven by the cellular environment. https://journals.biologists.com/dev/art